@Article{ZaninMaSiMaCoLo:2014:GrCaNa,
author = "Zanin, Hudson and Margraf-Ferreira, A. and Silva, N. S. Da and
Marciano, F. R. and Corat, Evaldo Jose and Lobo, A. O.",
affiliation = "{Instituto Nacional de Pesquisas Espaciais (INPE)} and Laboratory
of Cell Biology and Tissue, Institute of Research and Development,
University of Vale Do Paraiba, Av. Shishima Hifumi, 2911, CEP:
12244-000 Sao Jose dos Campos, SP, Brazil and Laboratory of Cell
Biology and Tissue, Institute of Research and Development,
University of Vale Do Paraiba, Av. Shishima Hifumi, 2911, CEP:
12244-000 Sao Jose dos Campos, SP, Brazil and Laboratory of
Biomedical Nanotechnology, Institute of Research and Development,
University of Vale Do Paraiba, Av. Shishima Hifumi, 2911, CEP:
12244-000 Sao Jose dos Campos, SP, Brazil and {Instituto Nacional
de Pesquisas Espaciais (INPE)} and Laboratory of Biomedical
Nanotechnology, Institute of Research and Development, University
of Vale Do Paraiba, Av. Shishima Hifumi, 2911, CEP: 12244-000 Sao
Jose dos Campos, SP, Brazil",
title = "Graphene and carbon nanotube composite enabling a new prospective
treatment for trichomoniasis disease",
journal = "Materials Science and Engineering C",
year = "2014",
volume = "41",
pages = "65--69",
month = "Aug.",
keywords = "graphene oxide, carbon nanotube oxide, composite, Tritrichomonas
foetus, drug carrier.",
abstract = "We report the synthesis and application of novel graphene oxide
and carbon nanotube oxide (GCN-O) composite. First, pristine
multi-walled carbon nanotube was prepared by chemical vapour
deposition furnace and then exfoliated and oxidised simultaneously
by oxygen plasma etching. The superficial and volumetric
compositions of GCN-O were measured by XPS spectroscopy and EDX
spectroscopy, respectively. Both XPS and EDX analyses evidence
that the GCN-O is composed of up to 20% of oxygen atoms. As a
result, GCN-O forms a stable colloidal aqueous solution and shows
to have strong interaction with the cell membrane of
Tritrichomonas foetus protozoa, making easy its application as a
drug carrier. Trichomoniasis infection of cattle is a devastating
disease for cattle producers, causing some damages to females and
fetus, and the abortion is the most serious result of this
disease. There is no effective treatment for trichomoniasis
infection yet. Therefore, new treatment, especially one with no
collateral effects in animals, is required. With this goal in
mind, our results suggest that water dispersible composite is a
novel nanomaterial, promising for Trichomoniasis infection
treatment and as therapeutic delivery agent as well.",
doi = "10.1016/j.msec.2014.04.020",
url = "http://dx.doi.org/10.1016/j.msec.2014.04.020",
issn = "0928-4931",
label = "scopus 2014-05 ZaninMaDaMaCoLo:2014:GrCaNa",
language = "en",
targetfile = "1-s2.0-S0928493114002124-main.pdf",
urlaccessdate = "27 abr. 2024"
}